ISCAS 2002

IEEE International Symposium

on Circuits and Systems

Sunday, 26 May 2002 - Wednesday, 29 May 2002

Scottsdale Princess Resort

Scottsdale, Arizona

ISCAS 2002 Theme: Circuits and Systems for Ubiquitous Computing


Deirdre R. Meldrum
University of Washington
Monday, 27 May

The availability of genome sequences for both prokaryotes and eukaryotes is laying the foundation for a revolution that will ultimately transform biology from a largely descriptive and reductionist discipline into a fundamentally predictive science. The growing ability to analyze whole biological systems based on genomic information is creating snapshots of cells at the transcriptional and translational level, which are providing preliminary insights into cellular complexity. However, to understand complex molecular outcomes such as cell proliferation, differentiation, apoptosis, and pathogenesis, it will be necessary to determine how the parts are integrated in time and space to form complex, dynamic cellular functions, and how cellular interactions create higher-order functions. Such analyses require the simultaneous measurement of many variables in real-time, and due to heterogeneity in cellular populations, these analyses need to be carried out for individual cells.

We propose to design and build fully integrated and automated microsystems for the interrogation of individual cells. This core technology will then be converted into modules designed for specific applications, which will push the limits of detection to the minimum, in some cases, to single molecule levels. This enabling technology will be directed towards specific research problems in two main areas: 1) automated detection of rare cells in cell populations, and 2) real-time analysis of metabolism in individual cells. Both areas are applicable to eukaryotes and prokaryotes, and depend on availability of genome sequence data, but not necessarily complete genomes. The integrated biologically-active microsystems we develop will push the limits of detection, tackle the module-to-module interconnect problem that is ubiquitous in all integrated microsystems, emphasize overall systems integration, and enable the production of comprehensive data sets. Technology required for success includes circuits and systems, systems on chips, MEMS, sensors, nanotechnology, and so on. Ultimately, these microsystems will have far- reaching applications for both basic and applied research in broad areas on biomedical systems biology.

The 2002 IEEE International Symposium on Circuits and Systems is sponsored by:
and supported by:
Texas Instruments
Date     Announcement
    6 March     Preliminary conference schedule available. See "Program" area of website.
    29 January     Session information for accepted papers is now available.
    19 January     The list of accepted papers has been posted. Please see the Paper Submission page for the link.
Tutorial Proposal Deadline         Friday, 21 September 2001
Paper Submission Deadline         Monday, 29 October 2001
Paper Acceptance Notification         Friday, 18 January 2002
Author Registration Deadline         Friday, 1 March 2002
Final Submission Deadline         Friday, 1 March 2002
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